ECS13
DESIGN, EX SITU, AND IN VIVO RESULTS OF THE JELLISEE ACCOMMODATING IOL
J. Schallhorn1,*
1University of California, San Francisco, San Francisco, United States
A sufficiently effective accommodating intraocular lens (IOL) to replace a cataractous or dysfunctional lens is not currently available, despite decades of development efforts. Using known biomechanical properties of the pediatric human lens, a shape changing accommodating IOL was designed and tested.
The JelliSee Accommodating IOL design was tested with FEA analysis and Zemax optical modeling. A prototype IOL was manufactured and tested with a custom lens stretcher and laser measurements. The prototype accommodating IOL was then tested in a primate. Based on the results in bench testing and the primate, the IOL was implanted in 10 human subjects outside the US
FEA analysis and Zemax optical modeling using the known forces of the human eye, predicted the JelliSee accommodating IOL would be capable of an amplitude of accommodation of 7 diopters. Results of optical bench testing and stretcher testing of a prototype JelliSee accommodating IOL also demonstrated excellent visual quality and an accommodation amplitude of 7 diopters. Primate testing demonstrated 7 diopters amplitude of accommodation up to 15 months post implantation. Preliminary results of human implantation have demonstrated a significant and sustained amplitude of accommodation similar to the results of ex-situ modeling and in vivo primate testing.
The JelliSee Accommodating IOL, based on the biomechanics of the pediatric human lens, has demonstrated a significant amplitude of accommodation ex situ and in vivo. Such an accommodating IOL has potential benefits for adults and children with a diseased or dysfunctional lens.
Schallhorn JM, Pantanelli SM, Lin CC, Al-Mohtaseb ZN, Steigleman WA 3rd, Santhiago MR, Olsen TW, Kim SJ, Waite AM, Rose-Nussbaumer JR. Multifocal and Accommodating Intraocular Lenses for the Treatment of Presbyopia: A Report by the American Academy of Ophthalmology. Ophthalmology. 2021 Oct;128(10):1469-1482. doi: 10.1016/j.ophtha.2021.03.013. Epub 2021 Mar 17. PMID: 33741376ESCRS24-ECS-5460